step three.3. Exposure Circumstances
Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).
Each other Bmi and you can weight were synchronised which have BMD, and BMC evidence plus the strongest Pearson’s correlation coefficients had been discovered anywhere between lbs and you will BMC in total cool and you may trochanter nations and you can new weakest ones was anywhere between Body mass index and you can femoral neck BMC. New correlations ranging from age and you may BMD and you may BMC symptoms had been bad (Table cuatro).
This-modified ratio out of BMD and BMC variation informed me by the Bmi and you will lbs was shown from inside the Table 5. Weight tended to inform you better differences in BMD and you can BMC shipments whatsoever the read skeletal web sites than the Body mass index. It was reflected by the steeper mountain (?) of your particular linear regression lines. Best difference in BMD and BMC delivery featured at trochanter BMC followed closely by lumbar BMC to own weight. Pounds is a vital predictor of BMD and BMC adaptation when you look at the older Iranian guys.
In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.
The brand new elements by which adipose tissue exerts results on the BMD reputation are not completely obvious. The newest putative device benefits away from fat for skeletal stability probably resides in this new character of numerous adipokines inside limbs building work because of affect each other formation and you may resorption. Has just, limbs could have been felt an endocrine body organ affecting lbs handle and you will sugar homoeostasis from the strategies Aubrey TX sugar daddies away from limbs-derived issues for example osteocalcin and you will osteopontin [23, 34–36]. The new putative crosstalk anywhere between pounds in addition to bones comprises a beneficial homoeostatic views program in which adipokines and you may molecules released by the osteoblasts and you can osteoclasts depict the hyperlink out-of a dynamic bone-adipose axis [34–36]. Being obese is additionally in the BMD from the sales away from androgen so you can estrogen , and therefore enhances limbs mass in folk [38, 39] and you can holds suit plasma quantities of insulin and you may controlling circumstances and additionally insulin-eg growth foundation-step one, leptin, and adiponectin . As well, carrying excess fat provides cushioning on stylish in case there are a beneficial slide . Yet not, the newest mechanisms by which all these events occur are still uncertain.